ABCB1 p.Phe978Leu
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PMID: 8104183
[PubMed]
Loo TW et al: "Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein."
No.
Sentence
Comment
126
Mutants with changes of Phe-978 to Ser, Leu, or Tyr all retained the ability to confer resistance to vinblastine, since drug-resistantcolonies were obtained after transfection with the corresponding mutant cDNAs.
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ABCB1 p.Phe978Leu 8104183:126:24
status: NEW166 Substitution of Phe-978 with Leu had an intermediate effect; drug transport was impaired for all four drugs with the greatest reduction occurring in the presence of colchicine and adriamycin.
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ABCB1 p.Phe978Leu 8104183:166:16
status: NEW
PMID: 16545467
[PubMed]
Shilling RA et al: "New light on multidrug binding by an ATP-binding-cassette transporter."
No.
Sentence
Comment
62
Another replacement in this cluster in TMH12 (F978L) reduces resistance to colchicine and daunomycin but has no significant effect on the resistance to vinblastine and actinomycin D [16].
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ABCB1 p.Phe978Leu 16545467:62:46
status: NEW60 Another replacement in this cluster in TMH12 (F978L) reduces resistance to colchicine and daunomycin but has no significant effect on the resistance to vinblastine and actinomycin D [16].
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ABCB1 p.Phe978Leu 16545467:60:46
status: NEW