ABCB1 p.Glu875Arg
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PMID: 21182301
[PubMed]
Loo TW et al: "The W232R suppressor mutation promotes maturation of a truncation mutant lacking both nucleotide-binding domains and restores interdomain assembly and activity of P-glycoprotein processing mutants."
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243
Therefore, we tested the effect of reversing the charges by constructing mutant G251V/T945E/ E875R.
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ABCB1 p.Glu875Arg 21182301:243:93
status: NEW244 It was found that the T945E/E875R combination but not individual T945E or E875R mutations promoted maturation of G251V (Figure 7D).
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ABCB1 p.Glu875Arg 21182301:244:28
status: NEWX
ABCB1 p.Glu875Arg 21182301:244:74
status: NEW260 (D) Whole cell extracts of cells expressing A52-tagged G251V (none) or G251V mutants containing opposite charges at positions 945 and 875 (T945E/E875, T954E, or E875R) were subjected to immunoblot analysis with monoclonal antibody against A52 or GAPDH.
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ABCB1 p.Glu875Arg 21182301:260:161
status: NEW