ABCB1 p.Ser993Ala
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PMID: 21182301
[PubMed]
Loo TW et al: "The W232R suppressor mutation promotes maturation of a truncation mutant lacking both nucleotide-binding domains and restores interdomain assembly and activity of P-glycoprotein processing mutants."
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196
(D) HEK 293 cells transfected with A52-tagged mutant G251V/W232R(TM4) containing mutations in potential hydrogen-bonding residues in TM6 (S344A, Q347A, S349A, S351A) or TM12 (Q990A, S992A, S993A) were cultured in the absence (-) or presence (þ) of cyclosporin A (cyclo A).
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ABCB1 p.Ser993Ala 21182301:196:189
status: NEW241 Maturation was not reduced by the Q990A, S992A, or S993A TM12 mutations (Figure 7C, lanes 7, 8, and 9).
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ABCB1 p.Ser993Ala 21182301:241:51
status: NEW