ABCB1 p.Trp708Arg
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PMID: 21182301
[PubMed]
Loo TW et al: "The W232R suppressor mutation promotes maturation of a truncation mutant lacking both nucleotide-binding domains and restores interdomain assembly and activity of P-glycoprotein processing mutants."
No.
Sentence
Comment
147
The effect of the W136R, W212R, W315R, W708R, and W855R mutations on maturation of wild-type P-gp was then tested.
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ABCB1 p.Trp708Arg 21182301:147:39
status: NEW149 All of the mutants except W708R (Figure 2D, lane 9) expressed the mature 170 kDa protein as the major product (Figure 2D, lanes 1, 3, 5, 7, and 11), and the amount of mature protein increased in the presence of cyclosporin A (Figure 2D, lanes 2, 4, 6, 8, and 12).
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ABCB1 p.Trp708Arg 21182301:149:26
status: NEW150 The major product in mutant W708R was the immature 150 kDa protein (Figure 2D, lane 9).
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ABCB1 p.Trp708Arg 21182301:150:28
status: NEW