ABCB1 p.Gly722Ala
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PMID: 21182301
[PubMed]
Loo TW et al: "The W232R suppressor mutation promotes maturation of a truncation mutant lacking both nucleotide-binding domains and restores interdomain assembly and activity of P-glycoprotein processing mutants."
No.
Sentence
Comment
57
The red balls show the locations of Trp232 and the processing mutations at positions 251 (G251V), 490 (ΔY490), 709 (P709A), 722 (G722A), and 1260 (L1260A).
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ABCB1 p.Gly722Ala 21182301:57:135
status: NEW67 Mutations were introduced into wild-type P-gp or processing mutants containing processing mutations in different domains (G251V in TMD1, ΔY490 in NBD1, P709A in the linker region, G722A in TMD2, or L1260A in NBD2) as described previously (28).
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ABCB1 p.Gly722Ala 21182301:67:186
status: NEW125 The W232R mutation was introduced into mutants P709A (linker region), G722A (TMD2), or L1260A (NBD2).
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ABCB1 p.Gly722Ala 21182301:125:70
status: NEW
PMID: 15530432
[PubMed]
Loo TW et al: "Thapsigargin or curcumin does not promote maturation of processing mutants of the ABC transporters, CFTR, and P-glycoprotein."
No.
Sentence
Comment
59
The processing mutations G300V (TM5) and G722A (TM7) are in TMD1 and TMD2, respectively.
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ABCB1 p.Gly722Ala 15530432:59:41
status: NEW70 Although the processing mutations (G251V, G300V, DY490, P709A, G722A, F804A, and P1194A) are located in different segments of P-gp, all the mutants could be rescued when expressed with drug substrates such as cyclosporin A.
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ABCB1 p.Gly722Ala 15530432:70:63
status: NEW90 We then compared the abilities of cyclosporin A, thapsigargin, and curcumin to induce maturation of P-gp processing mutants G251V, G300V, DY490, P709A, G722A, F804A, and P1194A.
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ABCB1 p.Gly722Ala 15530432:90:152
status: NEW