ABCB1 p.Cys431Trp
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PMID: 20623213
[PubMed]
Crouthamel MH et al: "A novel MDR1 GT1292-3TG (Cys431Leu) genetic variation and its effect on P-glycoprotein biologic functions."
No.
Sentence
Comment
220
If these mutations were to occur independently of one another, they would result in a Cys431Phe transition (G1292T) or Cys431Trp transition (T1293G).
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ABCB1 p.Cys431Trp 20623213:220:119
status: NEW222 Regardless, if our hypothesis is correct in that the change in P-gp-mediated resistance and uptake is due to the increase in size and hydrophobicity of the resulting amino acid 431 compared with Cys, we believe that the Cys431Phe and Cys431Trp may have similar results to the Cys431Leu transition, and remains to be investigated.
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ABCB1 p.Cys431Trp 20623213:222:234
status: NEW