ABCB1 p.Phe343Tyr
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PMID: 17848563
[PubMed]
Loo TW et al: "Suppressor mutations in the transmembrane segments of P-glycoprotein promote maturation of processing mutants and disrupt a subset of drug-binding sites."
No.
Sentence
Comment
99
Some changes in TM5 (I306A or G) or in TM6 (F343Y) in the ⌬Y490 P-gp mutant also caused the mutant protein to be unstable because cells expressing these mutants contained relatively large amounts of a 130-kDa degradation product (21).
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ABCB1 p.Phe343Tyr 17848563:99:44
status: NEW101 In cells expressing mutant F343Y/⌬Y490, the 130-kDa protein was the major product.
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ABCB1 p.Phe343Tyr 17848563:101:27
status: NEW