ABCB1 p.Tyr950Cys
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PMID: 16442101
[PubMed]
Frelet A et al: "Insight in eukaryotic ABC transporter function by mutation analysis."
No.
Sentence
Comment
516
ATP hydrolysis promoted the interaction between the extracellular ends of TM1 and TM11 as shown by mutating M68 and M69 (TM1) and Y950C, Y953, A954, F957 (TM11) into cysteines followed by cross-linking experiments of different combinations of these mutants [255].
X
ABCB1 p.Tyr950Cys 16442101:516:130
status: NEW
PMID: 16042402
[PubMed]
Loo TW et al: "ATP hydrolysis promotes interactions between the extracellular ends of transmembrane segments 1 and 11 of human multidrug resistance P-glycoprotein."
No.
Sentence
Comment
158
Finally, we tested whether mutants M68C(TM1)/Y950C- (TM11), M68C(TM1)/Y953C(TM11), M68C(TM1)/A954C- (TM11), M69C(TM1)/A954C(TM11), and M69C(TM1)/ F957C(TM11) that showed ATP-dependent cross-linking were still active.
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ABCB1 p.Tyr950Cys 16042402:158:45
status: NEW