ABCB1 p.Ser35Ile
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PMID: 15709779
[PubMed]
Kaur P et al: "Biochemical characterization of domains in the membrane subunit DrrB that interact with the ABC subunit DrrA: identification of a conserved motif."
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255
Since S35A mutation in the N-terminal domain and C260A and A270S in the C-terminal domain showed no change in the doxorubicin resistance phenotype as compared to the wild type, nonconservative mutations of these three residues, including S35I, C260E, and A270Y, were created.
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ABCB1 p.Ser35Ile 15709779:255:238
status: NEW256 S35I mutation conferred doxorubicin sensitivity, while cells containing C260E and A270Y still remained relatively unaffected (Table 2).
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ABCB1 p.Ser35Ile 15709779:256:0
status: NEW258 The most severe reduction in the levels of both DrrA and DrrB is seen with S35I mutation (Figure 7).
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ABCB1 p.Ser35Ile 15709779:258:75
status: NEW259 G25A and E26D also showed significantly reduced levels of DrrA and DrrB, although these are less affected as compared to S35I.
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ABCB1 p.Ser35Ile 15709779:259:121
status: NEW