ABCB1 p.Ser35Ala
[switch to full view]Comments [show]
None has been submitted yet.
PMID: 15709779
[PubMed]
Kaur P et al: "Biochemical characterization of domains in the membrane subunit DrrB that interact with the ABC subunit DrrA: identification of a conserved motif."
No.
Sentence
Comment
253
These changes include S23A, G25A, E26D, and S35A in the N-terminal domain and C260A and A270S in the C-terminal domain.
X
ABCB1 p.Ser35Ala 15709779:253:44
status: NEW255 Since S35A mutation in the N-terminal domain and C260A and A270S in the C-terminal domain showed no change in the doxorubicin resistance phenotype as compared to the wild type, nonconservative mutations of these three residues, including S35I, C260E, and A270Y, were created.
X
ABCB1 p.Ser35Ala 15709779:255:6
status: NEW257 Protein expression analysis by SDS-PAGE showed that most mutations, except S23A, S35A, and A270Y show varying degrees of reduction in the levels of DrrA and DrrB.
X
ABCB1 p.Ser35Ala 15709779:257:81
status: NEW