ABCB1 p.Ala229Val
[switch to full view]Comments [show]
None has been submitted yet.
PMID: 12391288
[PubMed]
Gruol DJ et al: "Evidence for the locations of distinct steroid and Vinca alkaloid interaction domains within the murine mdr1b P-glycoprotein."
No.
Sentence
Comment
119
It contains two closely spaced mutations, A229V and W231L.
X
ABCB1 p.Ala229Val 12391288:119:42
status: NEW127 In total, the process identified five new mutations, two of which (A229V, S308L) involve amino acids that had not been previously identified as contributing to steroid interactions with the P-gp.
X
ABCB1 p.Ala229Val 12391288:127:67
status: NEW131 The percentage of normalized change in resistance (N.C.R) is defined by the equation: N.C.R ϭ 100% ϫ (VAR IC50 - MS23IC50 )/(MS23 IC50 - W7TB IC50) Cell Line Vincristine Daunomycin Dexamethasone Puromycin Colchicine Mutation MSPD-10 N.C. ` ``` `` `` W231C MSPT-7 `` ``` ``` ``` ` A229V, W231L MSPD-60 `` N.C. ``` `` `` A301D MSMP-1 ` `` `` `` ``` S308L MSAC-52 ` N.C. `` N.C. ϩϩϩϩ L338F N.C., no change; ϩϩϩϩ, NCR increase Ն200%; `, NCR decrease Ն33%; ``, Ն67%; ```, Ն100%.
X
ABCB1 p.Ala229Val 12391288:131:292
status: NEW