ABCB1 p.Ala301Asp
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PMID: 12391288
[PubMed]
Gruol DJ et al: "Evidence for the locations of distinct steroid and Vinca alkaloid interaction domains within the murine mdr1b P-glycoprotein."
No.
Sentence
Comment
117
The A301D mutation occurs in the same residue as the A301T and A301V mutations.
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ABCB1 p.Ala301Asp 12391288:117:4
status: NEW131 The percentage of normalized change in resistance (N.C.R) is defined by the equation: N.C.R ϭ 100% ϫ (VAR IC50 - MS23IC50 )/(MS23 IC50 - W7TB IC50) Cell Line Vincristine Daunomycin Dexamethasone Puromycin Colchicine Mutation MSPD-10 N.C. ` ``` `` `` W231C MSPT-7 `` ``` ``` ``` ` A229V, W231L MSPD-60 `` N.C. ``` `` `` A301D MSMP-1 ` `` `` `` ``` S308L MSAC-52 ` N.C. `` N.C. ϩϩϩϩ L338F N.C., no change; ϩϩϩϩ, NCR increase Ն200%; `, NCR decrease Ն33%; ``, Ն67%; ```, Ն100%.
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ABCB1 p.Ala301Asp 12391288:131:331
status: NEW153 Daunomycin was used to evaluate the effect of the A301D mutation, expressed in the MSPD-60 cells, on the inhibitory activity of 5betaPodo.
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ABCB1 p.Ala301Asp 12391288:153:50
status: NEW298 Multiple mutations were also found at the A301 residue (A301V, A301T, A301D), although much less frequently than the changes at W231.
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ABCB1 p.Ala301Asp 12391288:298:70
status: NEW