ABCB1 p.Asn428Cys
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PMID: 12226074
[PubMed]
Loo TW et al: "The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence."
No.
Sentence
Comment
77
Cross-linking involving residues G427C, N428C, and S434C was not done because the single cysteine mutants, G427C and S434C, showed little or no activity (Ͻ5%), while N428C was defectively processed and rapidly degraded.
X
ABCB1 p.Asn428Cys 12226074:77:40
status: NEWX
ABCB1 p.Asn428Cys 12226074:77:172
status: NEW