ABCB1 p.Phe978Ser
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PMID: 10724034
[PubMed]
Hafkemeyer P et al: "Chemoprotection of hematopoietic cells by a mutant P-glycoprotein resistant to a potent chemosensitizer of multidrug-resistant cancers."
No.
Sentence
Comment
186
Other mutations in close proximity, e.g., F978A and F978S, affect primarily the drug resistance profile of P-gp (Loo and Clarke, 1993).
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ABCB1 p.Phe978Ser 10724034:186:52
status: NEW
PMID: 8104183
[PubMed]
Loo TW et al: "Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein."
No.
Sentence
Comment
120
To test theeffects of other changes to these two residues, site-directed mutagenesis was used to change either Phe-335 or Phe-978 to serine (polar residue), leucine (small non-polar residue),or to tyrosine (aromatic residue withpolar side chain).
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ABCB1 p.Phe978Ser 8104183:120:122
status: NEW126 Mutants with changes of Phe-978 to Ser, Leu, or Tyr all retained the ability to confer resistance to vinblastine, since drug-resistantcolonies were obtained after transfection with the corresponding mutant cDNAs.
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ABCB1 p.Phe978Ser 8104183:126:24
status: NEW127 No colchicine-resistant colonies, however, were observed after transfection of cells with cDNAs coding for mutants Phe-978 Ser or Leu.
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ABCB1 p.Phe978Ser 8104183:127:115
status: NEW