ABCB1 p.Tyr953Cys
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PMID: 10585407
[PubMed]
Loo TW et al: "Identification of residues in the drug-binding domain of human P-glycoprotein. Analysis of transmembrane segment 11 by cysteine-scanning mutagenesis and inhibition by dibromobimane."
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120
Fig. 5 shows that the majority of the mutants, except for G939C, F942C, T945C, and Y953C, were not affected by treatment with dBBn.
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ABCB1 p.Tyr953Cys 10585407:120:83
status: NEW121 The activities of mutants F943C and Y953C were slightly inhibited by dBBn (38 and 26% respectively).
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ABCB1 p.Tyr953Cys 10585407:121:36
status: NEW