ABCB1 p.Phe957Cys
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PMID: 10585407
[PubMed]
Loo TW et al: "Identification of residues in the drug-binding domain of human P-glycoprotein. Analysis of transmembrane segment 11 by cysteine-scanning mutagenesis and inhibition by dibromobimane."
No.
Sentence
Comment
111
All the mutants, except F957C, yielded the mature 170-kDa protein as the major product (data not shown).
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ABCB1 p.Phe957Cys 10585407:111:24
status: NEW112 Mutant F957C may be unstable and susceptible to proteolytic digestion.
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ABCB1 p.Phe957Cys 10585407:112:7
status: NEW113 Immunoblots of cell extracts of HEK 293 transfected with mutant F957C showed the presence of only degradation products (data not shown).
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ABCB1 p.Phe957Cys 10585407:113:64
status: NEW