ABCC7 p.Thr1142Phe
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No.
Sentence
Comment
249
The interpretation of ar- residues immediately adjacent to S341, DPC bound with an affinity close to that of the wild-type channel (S341A-ylaminobenzoate inhibition of macroscopic Cl0 secretion is, at best, difficult because of their nonselectivity for Cl0 M1140I-T1142F).
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ABCC7 p.Thr1142Phe 9922378:249:264
status: NEW
PMID: 7522483
[PubMed]
McDonough S et al: "Novel pore-lining residues in CFTR that govern permeation and open-channel block."
No.
Sentence
Comment
74
That is, the triple mutant S341A-M11401-T1142F bound DPC more tightly than S341A alone, with an affinity close to that of the wild-type channel (Figure 3D; Figure 4).
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ABCC7 p.Thr1142Phe 7522483:74:40
status: NEW84 E,,,, the reversal potential, determined empirically from the voltage steps; Triple, S341A-M11401-T1142F mutant.
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ABCC7 p.Thr1142Phe 7522483:84:98
status: NEW111 Open circles, wild-type; closed circles, T1134F; open boxes, S341A; closed boxes, triple mutation (S341A-Mll- 401-T1142F).
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ABCC7 p.Thr1142Phe 7522483:111:114
status: NEW158 The sequence M11401-S1141-T1142F in TM 12 restores DPC binding to the S341A mutant.
X
ABCC7 p.Thr1142Phe 7522483:158:26
status: NEW