ABCC7 p.Ala198Cys
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PMID: 9724537
[PubMed]
Akabas MH et al: "Channel-lining residues in the M3 membrane-spanning segment of the cystic fibrosis transmembrane conductance regulator."
No.
Sentence
Comment
105
The baseline conductance of the oocytes was generally less than 2.5 µS. The average cAMP-stimulated CFTR conductance for the cysteine-substitution mutants ranged between 49 µS for P205C and 142 µS for the A198C mutant (Figure 3A); for wild type the average conductance was 108 µS. The cAMP-stimulated current reached a plateau within 22 min in oocytes expressing wild-type CFTR.
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ABCC7 p.Ala198Cys 9724537:105:220
status: NEW