ABCC7 p.Cys343Thr
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PMID: 21796426
[PubMed]
Holstead RG et al: "Functional Differences in Pore Properties Between Wild-Type and Cysteine-Less Forms of the CFTR Chloride Channel."
No.
Sentence
Comment
67
As shown in Fig. 3, single-channel conductance was significantly reduced in C343L, significantly increased in C343A as well as C343S and not significantly changed in C343T and C343V.
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ABCC7 p.Cys343Thr 21796426:67:166
status: NEW138 Since C343T (unlike C343S) was not associated with a significant change in single-channel conductance (Fig. 3), a cys-less construct in which C343 is replaced by threonine, rather than serine, might be considered to retain wild-type channel properties more faithfully.
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ABCC7 p.Cys343Thr 21796426:138:6
status: NEW