ABCC7 p.Phe1296Ala
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PMID: 20876359
[PubMed]
Szollosi A et al: "Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2."
No.
Sentence
Comment
152
Again, Po;bas of the double mutant F1296A/N1303Q was 10-fold larger than that of WT or the single mutants F1296A and N1303Q (Fig. S5, A-C), producing a negative Gint for the mutant cycle built on Po;bas/(1Po;bas) values (Fig. S5 D), even though in this case the overall free energy change (1.18 ± 0.84 kT) could not be claimed significantly different from zero because of the smaller Po;bas values obtained for WT in this set of experiments (Fig. S5 C, black).
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ABCC7 p.Phe1296Ala 20876359:152:35
status: NEWX
ABCC7 p.Phe1296Ala 20876359:152:114
status: NEW