ABCC7 p.Trp401Ile
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PMID: 20421370
[PubMed]
Tsai MF et al: "Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel."
No.
Sentence
Comment
124
Similar macroscopic experiments were conducted with W401I and W401Y mutations.
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ABCC7 p.Trp401Ile 20421370:124:52
status: NEW125 The shorter time constant was not significantly affected by either of the mutations (Fig. 3 D), whereas the second time constant (Fig. 3 E) was shortened by nonaromatic substitutions of W401 (W401I) but increased by the conservative W401Y mutation.
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ABCC7 p.Trp401Ile 20421370:125:192
status: NEW
PMID: 20861014
[PubMed]
Tsai MF et al: "Optimization of the degenerated interfacial ATP binding site improves the function of disease-related mutant cystic fibrosis transmembrane conductance regulator (CFTR) channels."
No.
Sentence
Comment
88
As expected, non-conservative substitutions of Trp-401 with Ile or Gly (W401I and W401G), which are unable to stack FIGURE 1.
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ABCC7 p.Trp401Ile 20861014:88:47
status: NEWX
ABCC7 p.Trp401Ile 20861014:88:72
status: NEW189 These mutations include W401G,W401I (Fig. 1, B-D), which eliminate a ring-ring stacking interaction, S1347G (supplemental Fig. S6), which may break a hydrogen bond between ATP and the NBD2 signature motif, and G1349I (supplemental Fig. S6), whose side chain likely protrudes into site 1 and causes a steric clash with ATP (22-24).
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ABCC7 p.Trp401Ile 20861014:189:30
status: NEW