ABCC7 p.Met156Val
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PMID: 19910674
[PubMed]
Ramalho AS et al: "Deletion of CFTR translation start site reveals functional isoforms of the protein in CF patients."
No.
Sentence
Comment
126
jointly mutated into valines and the respective stable cells wereanalysedbyimmunoblotforCFTR.ResultsinFig.5A reveal the presence of two proteins (D and E) for single mutants of M82V, M150V, M152V and M156V (lanes 36, respectively) and also for the double mutants M150V/ M152, M150V/M156V and M152V/M156V (lanes 7-9).
X
ABCC7 p.Met156Val 19910674:126:200
status: NEWX
ABCC7 p.Met156Val 19910674:126:282
status: NEWX
ABCC7 p.Met156Val 19910674:126:298
status: NEW140 Lanes 3-10 correspond to the proteins produced by the methionines mutants all in the c.120del23-CFTR pNUT background: lane 3, M82V; lane 4, M150V; lane 5 M152V; lane 6, M156V; lane 7, M150V/M152V; lane 8, M150V/M156V; lane 9, M152V/M156V; lane 10, M150V/M152V/M156V.
X
ABCC7 p.Met156Val 19910674:140:169
status: NEWX
ABCC7 p.Met156Val 19910674:140:211
status: NEWX
ABCC7 p.Met156Val 19910674:140:232
status: NEWX
ABCC7 p.Met156Val 19910674:140:260
status: NEW144 Lanes 2-8 all in pSP73: 2, CFTR exons 2-24; 3, M82V/ M150V/M152V/M156V; 4, M82V/M150V/M152V; 5, M82/M152V; 6, M82V/M150V;7, M150; 8, M82V.
X
ABCC7 p.Met156Val 19910674:144:65
status: NEW148 However, when the triple mutant (M150V/M152V/M156V) was analysed (lane 10, Fig.5A), only the lower form (E ~128 kDa) could be detected.
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ABCC7 p.Met156Val 19910674:148:45
status: NEW