ABCC7 p.Gln552Cys
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PMID: 19114635
[PubMed]
Wang X et al: "Mutations at the signature sequence of CFTR create a Cd(2+)-gated chloride channel."
No.
Sentence
Comment
23
On the other hand, negligible effects of Cd2+ were seen with T547C, Q552C, and R553C, indicating that a specific region of the signature sequence is involved in transmitting the signal of Cd2+ binding to the gate.
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ABCC7 p.Gln552Cys 19114635:23:68
status: NEW106 It appears that when cysteine is engineered outside the signature sequence (i.e., T547C and R553C) or at the C-terminal end of the signature sequence (i.e., Q552C), ATP remains a much better ligand than Cd2+ (e.g., Fig. 6 B).
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ABCC7 p.Gln552Cys 19114635:106:157
status: NEW