ABCC7 p.Gly970Ala
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PMID: 18597042
[PubMed]
Mornon JP et al: "Atomic model of human cystic fibrosis transmembrane conductance regulator: membrane-spanning domains and coupling interfaces."
No.
Sentence
Comment
254
Indeed, in our CFTR model, substitution of G178 by any other residue results in a steric hindrance with the ICL2 main chain (3.5 between the Ca atoms of G178 and V260), while G970A is the only substitution that might be accommodated without steric incompatibility with ICL4 (4.7 between the Ca atoms of G970 and F1052) (Fig. 7).
X
ABCC7 p.Gly970Ala 18597042:254:182
status: NEW
PMID: 8910333
[PubMed]
Seibert FS et al: "Cytoplasmic loop three of cystic fibrosis transmembrane conductance regulator contributes to regulation of chloride channel activity."
No.
Sentence
Comment
88
The G970A and G970M alterations resulted in efflux levels similar to wild-type, suggesting that amino acid size was not the major factor determining disturbance of CFTR function.
X
ABCC7 p.Gly970Ala 8910333:88:4
status: NEW