ABCC7 p.Arg1128Glu
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PMID: 18449561
[PubMed]
Zhou JJ et al: "Identification of positive charges situated at the outer mouth of the CFTR chloride channel pore."
No.
Sentence
Comment
60
As shown in Fig. 2, similar inward rectification is observed in the charge-reversing mutants R104E, R117E, and K335E and to a much lesser extent, R1128E, under symmetrical ionic conditions in excised membrane patches.
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ABCC7 p.Arg1128Glu 18449561:60:146
status: NEW78 The mutations K114E, K329E, K892E, R899E, and R1128E did not affect unitary current amplitude at any voltage (Fig. 4b), consistent with these residues not being involved in Cl- permeation.
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ABCC7 p.Arg1128Glu 18449561:78:46
status: NEW91 All mutants depicted (R104Q, R117Q, K335A, R1128Q, R104E, R117E, K335E, R1128E) showed rectification ratios significantly different from wild type (asterisk P<0.05).
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ABCC7 p.Arg1128Glu 18449561:91:72
status: NEW