ABCC7 p.Val510Gly
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PMID: 17911111
[PubMed]
Wang Y et al: "Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein."
No.
Sentence
Comment
68
The mutants were expressed in HEK 293 cells at 37 °C, and whole cell extracts were subjected to immunoblot analysis. Fig. 2B shows that changing Val510 to Thr, Gly, Ala, Ser, or Asp promoted maturation of Cys-less CFTR.
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ABCC7 p.Val510Gly 17911111:68:150
status: NEW70 Stable BHK cell lines expressing mutants V510A, V510C, V510S, V510G, or V510D were generated for use in iodide efflux assays.
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ABCC7 p.Val510Gly 17911111:70:62
status: NEW73 The results of mutants V510C, V510S, or V510G are not shown for clarity.
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ABCC7 p.Val510Gly 17911111:73:40
status: NEW82 ACCELERATED PUBLICATION: CFTR TM Domain Cross-linking 33248 To test whether the Val510 changes could also promote maturation of ⌬F508 CFTR (in a wild-type background), we introduced the Val510 mutations that promoted maturation of Cys-less CFTR (Val510 to Cys, Gly, Ala, Ser, Asp, or Thr) into ⌬F508 CFTR.
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ABCC7 p.Val510Gly 17911111:82:254
status: NEW
PMID: 20590134
[PubMed]
Loo TW et al: "The V510D suppressor mutation stabilizes DeltaF508-CFTR at the cell surface."
No.
Sentence
Comment
178
While introduction of V510D into Cys-less or ΔF508-CFTRs promoted maturation, the Cys-less mutant was different because its maturation could also be promoted by changing Val510 to Thr, Cys, Gly, Ala, or Ser.
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ABCC7 p.Val510Gly 20590134:178:176
status: NEW