ABCC7 p.Val510Thr
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PMID: 17911111
[PubMed]
Wang Y et al: "Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein."
No.
Sentence
Comment
67
Cys-less mutants in which residue Val510 was changed to Pro, Thr, Tyr, Gly, Ala, Ser, Leu, Asp, Phe, or Trp were constructed.
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ABCC7 p.Val510Thr 17911111:67:34
status: NEW68 The mutants were expressed in HEK 293 cells at 37 °C, and whole cell extracts were subjected to immunoblot analysis. Fig. 2B shows that changing Val510 to Thr, Gly, Ala, Ser, or Asp promoted maturation of Cys-less CFTR.
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ABCC7 p.Val510Thr 17911111:68:150
status: NEW
PMID: 20590134
[PubMed]
Loo TW et al: "The V510D suppressor mutation stabilizes DeltaF508-CFTR at the cell surface."
No.
Sentence
Comment
178
While introduction of V510D into Cys-less or ΔF508-CFTRs promoted maturation, the Cys-less mutant was different because its maturation could also be promoted by changing Val510 to Thr, Cys, Gly, Ala, or Ser.
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ABCC7 p.Val510Thr 20590134:178:176
status: NEW