ABCC7 p.Val510*
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PMID: 17911111
[PubMed]
Wang Y et al: "Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein."
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Sentence
Comment
25
The Cys-less CFTR cDNA was also modified to include the V510X mutations.
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ABCC7 p.Val510* 17911111:25:56
status: NEW27 The V510X mutations were then introduced into ⌬F508 CFTR as described above.
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ABCC7 p.Val510* 17911111:27:4
status: NEW83 The ⌬F508 CFTR/V510X mutants were expressed in HEK 293 cells at 37 °C, and whole cell extracts were subjected to immunoblot analysis. Fig. 2D shows that introduction of an Asp mutation at position 510 was most effective in promoting maturation of ⌬F508 CFTR.
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ABCC7 p.Val510* 17911111:83:22
status: NEW