ABCC7 p.Arg1030Glu
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PMID: 16442101
[PubMed]
Frelet A et al: "Insight in eukaryotic ABC transporter function by mutation analysis."
No.
Sentence
Comment
368
R1030E did not alter the anion permeability sequence although PI/PCl values were increased [18].
X
ABCC7 p.Arg1030Glu 16442101:368:0
status: NEW
PMID: 17043152
[PubMed]
Aubin CN et al: "Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel."
No.
Sentence
Comment
211
Unfortunately we were unable to identify currents associated with R1030E, although this mutant was previously expressed in another mammalian cell line (Anderson et al., 1991); this previous study did not note any changes in pore properties associated with this mutant.
X
ABCC7 p.Arg1030Glu 17043152:211:66
status: NEW
No.
Sentence
Comment
104
Thus, depending on the experimental tants, R347E and R1030E, did not alter the anion perme- conditions and whether block of the channel by I0 is con- ability sequence, although PI/PCl values were increased.
X
ABCC7 p.Arg1030Glu 9922375:104:53
status: NEW
No.
Sentence
Comment
432
This behavior is consistent with the notion that iodide can reside in the channel with-(TM1), K335E (TM6), R347E (TM6), and R1030E (TM10).
X
ABCC7 p.Arg1030Glu 9922376:432:124
status: NEW
PMID: 9674722
[PubMed]
Schwiebert EM et al: "Cystic fibrosis: a multiple exocrinopathy caused by dysfunctions in a multifunctional transport protein."
No.
Sentence
Comment
246
Mutations in TMD2 cluster in ␣-helix a loop between predicted ␣-helices 10 and 11 and include R1030E, R1066H, R1066C, R1066L, and R1070Q (100).
X
ABCC7 p.Arg1030Glu 9674722:246:108
status: NEW
PMID: 9879057
[PubMed]
Gallet X et al: "Topological model of membrane domain of the cystic fibrosis transmembrane conductance regulator."
No.
Sentence
Comment
232
Mutations associated with mild forms of cystic fibrosis (R117H, R334W, and R347P) implicate three of our inner pore residues in the chloride conductance.50 In other studies, basic amino acids of membrane helices were replaced by acidic residues (K95D, K335E, R347E, and R1030E).
X
ABCC7 p.Arg1030Glu 9879057:232:270
status: NEW236 Mutations associated with mild forms of cystic fibrosis (R117H, R334W, and R347P) implicate three of our inner pore residues in the chloride conductance.50 In other studies, basic amino acids of membrane helices were replaced by acidic residues (K95D, K335E, R347E, and R1030E).
X
ABCC7 p.Arg1030Glu 9879057:236:270
status: NEW
PMID: 9379167
[PubMed]
Tabcharani JA et al: "Halide permeation in wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels."
No.
Sentence
Comment
264
Arg347 May Contribute to a Weak Field Strength Site for Iodide High macroscopic PI/PCl ratios have been reported previously for CFTR channels in which positively charged residues in the membrane spanning regions were mutated to negatively charged residues (K95E, 1.43; K335E, 1.37; R347E, 0.9; R1030E, 0.81; Anderson et al., 1991).
X
ABCC7 p.Arg1030Glu 9379167:264:294
status: NEW289 Arg347 May Contribute to a Weak Field Strength Site for Iodide High macroscopic PI/PCl ratios have been reported previously for CFTR channels in which positively charged residues in the membrane spanning regions were mutated to negatively charged residues (K95E, 1.43; K335E, 1.37; R347E, 0.9; R1030E, 0.81; Anderson et al., 1991).
X
ABCC7 p.Arg1030Glu 9379167:289:294
status: NEW
PMID: 9089437
[PubMed]
Cheung M et al: "Locating the anion-selectivity filter of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel."
No.
Sentence
Comment
205
Curiously, neither of these mutations nor the mutations R347E and R1030E were reported to alter the Cl- to Naϩ permeability ratio (PCl/PNa), and the latter two mutations had minimal effects on halide permeability or conductance ratios (Anderson et al., 1991b).
X
ABCC7 p.Arg1030Glu 9089437:205:66
status: NEW
PMID: 1375035
[PubMed]
Welsh MJ et al: "Cystic fibrosis transmembrane conductance regulator: a chloride channel with novel regulation."
No.
Sentence
Comment
92
Mutation of 2 other basic residues, R347E and R1030E, did not change the selectivity sequence.
X
ABCC7 p.Arg1030Glu 1375035:92:46
status: NEW