ABCC7 p.Arg80Glu
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PMID: 17043152
[PubMed]
Aubin CN et al: "Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel."
No.
Sentence
Comment
98
Mutations that did not alter I-V shape (R80E, R242E, R933E, and R1102E) also had no significant effect on unitary conductance (Fig. 4 D).
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ABCC7 p.Arg80Glu 17043152:98:40
status: NEW149 Under these conditions, current carried not only by wild-type CFTR, but also by each of the channel mutants R303E, R352E (Fig. 10), R80E, R242E, R933E, R1102E, and R352Q (not depicted) showed reversal potentials that were not significantly different from the calculated Cl- equilibrium potential (+33.4 mV).
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ABCC7 p.Arg80Glu 17043152:149:132
status: NEW206 Examples of similar data obtained from three to four patches for these channel variants and also for R80E, R242E, R352Q, R933E, and R1102E (not depicted).
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ABCC7 p.Arg80Glu 17043152:206:101
status: NEW