ABCC7 p.Arg303Lys
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PMID: 17043152
[PubMed]
Aubin CN et al: "Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel."
No.
Sentence
Comment
67
Charge-conservative R303K and R352K mutations were associated with wild type like linear I-V relationships (Fig. 3 A).
X
ABCC7 p.Arg303Lys 17043152:67:20
status: NEW
PMID: 17293558
[PubMed]
St Aubin CN et al: "Identification of a second blocker binding site at the cytoplasmic mouth of the cystic fibrosis transmembrane conductance regulator chloride channel pore."
No.
Sentence
Comment
109
charge-conserving R303K mutant did not significantly affect the Kd value for suramin inhibition (Fig. 6).
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ABCC7 p.Arg303Lys 17293558:109:18
status: NEW
PMID: 17397825
[PubMed]
Zhou JJ et al: "Molecular mechanism of arachidonic acid inhibition of the CFTR chloride channel."
No.
Sentence
Comment
38
Thus, while the charge conservative K95R and R303K mutations were not associated with a significant increase in Kd (PN0.3, two-tailed t-test) all mutations which neutralized or reversed either of these two positive charges were associated with a significant increase in Kd (Fig. 2).
X
ABCC7 p.Arg303Lys 17397825:38:45
status: NEW