ABCC7 p.Gln98Ala
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PMID: 15504721
[PubMed]
Ge N et al: "Direct comparison of the functional roles played by different transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore."
No.
Sentence
Comment
76
However, the unitary conductance was drastically reduced by some mutations in TM1 (K95Q, Q98A, P99A) and TM6 (R334K, F337A) (Figs. 2-4).
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ABCC7 p.Gln98Ala 15504721:76:89
status: NEW82 In most cases macroscopic I-V relationships were linear or weakly inwardly rectifying in the presence of symmetrical high Cl- concentra- tions (as quantified in Fig. 6), although particularly strong inward rectification was observed in Q98A, P99A, and R334K.
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ABCC7 p.Gln98Ala 15504721:82:236
status: NEW102 The weakest block by Au(CN)2 - was observed in K95Q, T338A, R334K, and Q98A, consistent with these residues perhaps being associated with permeant anion binding sites inside the pore.
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ABCC7 p.Gln98Ala 15504721:102:71
status: NEW119 Some mutants that significantly affect both unitary conductance and Au(CN)2 - block were found to be without effect on SCN- permeability (Q98A, V318A, R334K, K335A).
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ABCC7 p.Gln98Ala 15504721:119:138
status: NEW