ABCC7 p.Asn505Ala
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PMID: 11788611
[PubMed]
Berger AL et al: "Mutations that change the position of the putative gamma-phosphate linker in the nucleotide binding domains of CFTR alter channel gating."
No.
Sentence
Comment
138
CFTR-N505A had gating kinetics similar to those of wild type; presumably the introduced Ala did not disrupt the structure to the same extent as when Cys was substituted for Asn.
X
ABCC7 p.Asn505Ala 11788611:138:5
status: NEW140 Inhibition by ADP, stimulation by PPi, and the EC50 for ATP stimulation were not altered by the N505C or N505A mutations (data not shown).
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ABCC7 p.Asn505Ala 11788611:140:105
status: NEW167 B, data from multiple patches. Asterisk indicates p Ͻ 0.05 compared with wild type CFTR; n ϭ 4 for CFTR-N505A and 6 for CFTR-N505C.
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ABCC7 p.Asn505Ala 11788611:167:116
status: NEW