ABCC7 p.Asn505Cys
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PMID: 16442101
[PubMed]
Frelet A et al: "Insight in eukaryotic ABC transporter function by mutation analysis."
No.
Sentence
Comment
299
[137] Q493A, Q1291A, N505C, N1303K Q493A and N505C reduced and increased the frequency of CO, respectively.
X
ABCC7 p.Asn505Cys 16442101:299:21
status: NEWX
ABCC7 p.Asn505Cys 16442101:299:45
status: NEW
PMID: 11788611
[PubMed]
Berger AL et al: "Mutations that change the position of the putative gamma-phosphate linker in the nucleotide binding domains of CFTR alter channel gating."
No.
Sentence
Comment
5
In contrast, N505C increased the frequency of channel opening, consistent with a role for Asn-505 in stabilizing the inactive state of the NBD.
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ABCC7 p.Asn505Cys 11788611:5:13
status: NEW136 Mutating Asn-505 in NBD1 Can Increase Channel Opening-The N505C mutation had an effect opposite to that of Q493A; it reduced the interburst interval and increased Po (Fig. 7).
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ABCC7 p.Asn505Cys 11788611:136:58
status: NEW140 Inhibition by ADP, stimulation by PPi, and the EC50 for ATP stimulation were not altered by the N505C or N505A mutations (data not shown).
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ABCC7 p.Asn505Cys 11788611:140:96
status: NEW141 The opposite effects of the Q493A and N505C mutations on gating are consistent with the expectation that these mutations might have different effects on the ␥-phosphate linker.
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ABCC7 p.Asn505Cys 11788611:141:38
status: NEW167 B, data from multiple patches. Asterisk indicates p Ͻ 0.05 compared with wild type CFTR; n ϭ 4 for CFTR-N505A and 6 for CFTR-N505C.
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ABCC7 p.Asn505Cys 11788611:167:137
status: NEW