ABCC7 p.Asp1425*
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PMID: 11022033
[PubMed]
Gentzsch M et al: "Localization of sequences within the C-terminal domain of the cystic fibrosis transmembrane conductance regulator which impact maturation and stability."
No.
Sentence
Comment
25
The antisense primers introducing the stop codon were the following: A1440X, 5Ј-TGATATCGGGC- CCCTATTGCCGGAAGAGGCTCCTCTCGTT-3Ј; S1435X, 5Ј-TGATAT- CGGGCCCCTACCTCTCGTTCAGCAGTTTCTGGATGG-3Ј; L1430X, 5Ј-TGATATCGGGCCCCTATTTCTGGATGGAATCGTACTGCCGCAC- 3Ј; D1425X, 5Ј-TGATATCGGGCCCCTAGTACTGCCGCACTTTGTTC- TCTTCTATG-3Ј; K1420X, 5Ј-TGATATCGGGCCCCTAGTTCTCTTCT- ATGACCAAAAATTGTTGGC-3Ј; V1415X, 5Ј-TGATATCGGGCCCCTA- CAAAAATTGTTGGCATTCCAGCATTGC-3Ј; C1410X, 5Ј-TGATATCG- * This work was supported by National Institutes of Health, NIDDK Grant DK54076 and a Fellowship from the Deutsche Forschungsgemeinschaft (to M. G.).
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ABCC7 p.Asp1425* 11022033:25:283
status: NEW
PMID: 12578973
[PubMed]
Ostedgaard LS et al: "Effects of C-terminal deletions on cystic fibrosis transmembrane conductance regulator function in cystic fibrosis airway epithelia."
No.
Sentence
Comment
116
A study in planar lipid bilayers reported little effect on open-state probability (Po) of D1425X or shorter deletions (22).
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ABCC7 p.Asp1425* 12578973:116:90
status: NEW184 These findings are consistent with previous reports that maturation and degradation of C-terminally truncated CFTR (S1455X and D1425X) is similar to WT in COS and BHK cells (19-21).
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ABCC7 p.Asp1425* 12578973:184:127
status: NEW