ABCC7 p.Phe433Cys
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PMID: 10893239
[PubMed]
Berger AL et al: "Differences between cystic fibrosis transmembrane conductance regulator and HisP in the interaction with the adenine ring of ATP."
No.
Sentence
Comment
8
The mutant channels CFTR-F429C, F430C, F433C, and F1232C showed no difference from wild-type CFTR, indicating that either the residues were not accessible to modification, or cysteine modification did not affect function.
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ABCC7 p.Phe433Cys 10893239:8:39
status: NEW77 When expressed in HeLa cells, CFTR-F429C, F430C, F433C, F446C, Y1219C, and F1232C all generated Cl-channel activity in excised, inside-out patches of membrane.
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ABCC7 p.Phe433Cys 10893239:77:49
status: NEW114 A summary of these data is shown in Fig. 4B. Wild-type, CFTR-F429C, F430C, F433C, and F1232C all exhibited similar levels of activity after treatment with 200 M MTSET in the absence of ATP.
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ABCC7 p.Phe433Cys 10893239:114:75
status: NEW126 Construct Po WT 0.29 Ϯ 0.04 F429C 0.21 Ϯ 0.03 F430C 0.30 Ϯ 0.03 F433C 0.21 Ϯ 0.03 F446C 0.34 Ϯ 0.06 Y1219C 0.26 Ϯ 0.07 F1232C 0.35 Ϯ 0.02 FIG. 2.
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ABCC7 p.Phe433Cys 10893239:126:82
status: NEW142 CFTR variant k M -1 s-1 Wild-type 23.1 Ϯ 6.4 F429C 27.0 Ϯ 16.7 F430C 34.6 Ϯ 22.8 F433C 19.0 Ϯ 5.5 F446C 36.1 Ϯ 15.8 Y1219C 75.5 Ϯ 20.1* F1232C 68.5 Ϯ 19.6 not interfere with the ability of MTSET to inactivate CFTR-Y1219C.
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ABCC7 p.Phe433Cys 10893239:142:99
status: NEW