ABCC1 p.Tyr440Gln
[switch to full view]Comments [show]
None has been submitted yet.
PMID: 18775981
[PubMed]
Grant CE et al: "Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)."
No.
Sentence
Comment
210
Transport by the two polar mutations Y440Q and Y440S was decreased by 75 to 80%, whereas the charged and neutral mutations decreased transport by more than 90% (Fig. 6A).
X
ABCC1 p.Tyr440Gln 18775981:210:37
status: NEW291 Other conservative (W) and nonconservative (A, E, Q, and S) substitutions of Tyr440 caused significant reductions in LTC4 transport ranging from 75% (Y440Q) to 90% (Y440A and Y440E).
X
ABCC1 p.Tyr440Gln 18775981:291:150
status: NEW