ABCC1 p.Ala481Gly
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PMID: 18775981
[PubMed]
Grant CE et al: "Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)."
No.
Sentence
Comment
140
A second double mutation, A481G/V482A, located in the G2 region also reduced LTC4 transport by 6-fold, and in this case, E217betaG transport was reduced to approximately one third of wild-type MRP1 levels (data not shown).
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ABCC1 p.Ala481Gly 18775981:140:26
status: NEW193 Mutations Included 23 M443L/Y440F/1441L 24 A481G/V482A/M483V/M485V 25 V479L/A481G/V482A/M483V/M485V 26 A493K/H494Q/S497L/N500S 27 V479L/A481G/V482A/M483V/M485V 28 V479L/A481G/V482A/M483V/N500S 29 A493K/H494Q/S497L/N500S/N506S 30 A493K/H494Q/S497L/N506S/T487M/K488R/T489A/Y490F consequence, it was technically impossible to determine an accurate Km for LTC4.
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ABCC1 p.Ala481Gly 18775981:193:43
status: NEWX
ABCC1 p.Ala481Gly 18775981:193:76
status: NEWX
ABCC1 p.Ala481Gly 18775981:193:136
status: NEWX
ABCC1 p.Ala481Gly 18775981:193:169
status: NEW