ABCC1 p.Ala1331Cys
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PMID: 16442101
[PubMed]
Frelet A et al: "Insight in eukaryotic ABC transporter function by mutation analysis."
No.
Sentence
Comment
138
The C682A (NBD1) mutation decreased the Kd value for ATP indicating increased affinity for this nucleotide while A1331C (NBD2) did not have any effect, suggesting that ATP binding at NBD1 at low concentration played a more important regulatory role than the binding at high ATP concentration and that ATP hydrolysis at NBD2 played a dominant role in the ATP-dependent LTC4 transport [92].
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ABCC1 p.Ala1331Cys 16442101:138:113
status: NEW