ABCC1 p.Arg1131Asp
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PMID: 15208328
[PubMed]
Situ D et al: "Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter."
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82
RESULTS Expression and Transport Properties of MRP1 Mutants Containing Opposite and Same Charge Substitutions of Arg1046 , Asp1084 , and Arg1131 in or Near TM13-15-In the first series of experiments, the importance of ionizable amino acids located in or near predicted TM13-15 for MRP1 protein expression and function were investigated by replacing Arg1046 and Arg1131 with Asp and Glu, respectively.
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ABCC1 p.Arg1131Asp 15208328:82:361
status: NEW