ABCC1 p.Ser1237Ala
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PMID: 11925441
[PubMed]
Zhang DW et al: "Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17."
No.
Sentence
Comment
3
Mutations S1233A, S1235A, S1237A, and Q1239A had no effect on any substrate tested.
X
ABCC1 p.Ser1237Ala 11925441:3:26
status: NEW112 Substitution of four hydrophilic amino acid residues within TM17 with Ala (S1233A, S1235A, S1237A, Q1239A) had no significant effect on the ability of MRP1 to confer resistance to any drug tested.
X
ABCC1 p.Ser1237Ala 11925441:112:91
status: NEW141 ATP-dependent transport of [3 H]E217betaG was also examined (Fig. 5), but none of the mutations S1233A, S1235A, Y1236F, S1237A, Q1239A, and T1241A had any effect.
X
ABCC1 p.Ser1237Ala 11925441:141:120
status: NEW199 With the exception of Tyr1236 , mutation of the amino acids with polar substituents predicted to be most distant from the membrane/cytoplasm interface (S1233A, S1235A, S1237A, and Q1239A) to Ala had no effect on the ability of MRP1 to confer resistance to any of the drugs tested.
X
ABCC1 p.Ser1237Ala 11925441:199:168
status: NEW