ABCC1 p.Thr1242Asp
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PMID: 11429411
[PubMed]
Zhang DW et al: "Identification of a nonconserved amino acid residue in multidrug resistance protein 1 important for determining substrate specificity: evidence for functional interaction between transmembrane helices 14 and 17."
No.
Sentence
Comment
239
The consequences of mutating mrp1A1239 and MRP1T1242, with the exception of the T1242D mutation, are qualitatively similar to those we observed following mutation of the highly conserved Trp1246 , which abolished drug resistance and E217betaG transport (30).
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ABCC1 p.Thr1242Asp 11429411:239:80
status: NEW266 Only substitution of Thr1242 with Asp affected transport of both E217betaG transport and, albeit to a lesser extent, LTC4.
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ABCC1 p.Thr1242Asp 11429411:266:21
status: NEW