ABCG8 p.Glu238Gln
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PMID: 16352607
[PubMed]
Zhang DW et al: "Functional asymmetry of nucleotide-binding domains in ABCG5 and ABCG8."
No.
Sentence
Comment
53
For G8, R111M-forward (5Ј-TCA GGC TGC GGG ATG GCC TCA CTA CTC-3Ј), R111M- reverse (5ЈGAG TAG TGA GGC CAT CCC GCA GCC TGA-3Ј), R111K-forward (5Ј-TCA GGC TGC GGG AAG GCC TCA CTA CTC-3Ј), R111K-reverse (5ЈGAG TAG TGA GGC CTT CCC GCA GCC TGA-3Ј), G216D-forward (5Ј-GGG GTG TCC GGG GAT GAG CGC CGA CGA-3Ј), G216D-reverse (5Ј-TCG TCG GCG CTC ATC CCC GGA CAC CCC-3Ј), V214IG215S-forward (5Ј-TAT GTA CGT GGG ATC TCC TCG GGT GAG CGC CGA-3Ј), V214IG215S-reverse (5Ј- TCG GCG CTC ACC CGA GGA GAT CCC ACG TAC ATA-3Ј), E238D-forward (5Ј-CTC ATT CTG GAT GAC CCC ACT TCT GGC-3Ј), E238D-reverse (5Ј-GCC AGA AGT GGG GTC ATC CAG AAT GAG-3Ј), E238Q-forward (5Ј-CTC ATT CTG GAT CAG CCC ACT TCT GGC-3Ј), and E238D-reverse (5Ј-GCC AGA AGT GGG CTG ATC CAG AAT GAG-3Ј).
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ABCG8 p.Glu238Gln 16352607:53:744
status: VERIFIED206 Substitution of the same residue to glutamine (G8-E238Q) resulted in relative reduction in binding of 8-azido[␣- 32 P]ATP and the trapping of 8-azido-[␣32 P]ADP to G8 without having a significant effect on nucleotide binding and trapping in G5.
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ABCG8 p.Glu238Gln 16352607:206:50
status: VERIFIED