ABCG5 p.Gln604Lys
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PMID: 15175352
[PubMed]
Gylling H et al: "Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity."
No.
Sentence
Comment
102
The Q604K polymorphism of the G5 gene was associated with obesity, low cholesterol absorption marker level, high serum fasting insulin level, and impaired whole-body glucose uptake, suggesting insulin resistance in men.
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ABCG5 p.Gln604Lys 15175352:102:4
status: VERIFIED131 The Q604K polymorphism of the G5 gene was associated with insulin sensitivity, at least in men.
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ABCG5 p.Gln604Lys 15175352:131:4
status: VERIFIED129 In the present study, the presence of the D19H polymorphic site seemed to prevent the increase of serum sitosterol ratio differently from the wild type in increasing cholestanol tertiles, suggesting an inhibitory effect on cholesterol absorption, and the compensatory increase in cholesterol synthesis in these subjects could be seen.
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ABCG5 p.Gln604Lys 15175352:129:4
status: NEW100 The Q604K polymorphism of the G5 gene was associated with obesity, low cholesterol absorption marker level, high serum fasting insulin level, and impaired whole-body glucose uptake, suggesting insulin resistance in men.
X
ABCG5 p.Gln604Lys 15175352:100:4
status: NEW101 The Q604K polymorphism of the G5 gene was associated with obesity, low cholesterol absorption marker level, high serum fasting insulin level, and impaired whole-body glucose uptake, suggesting insulin resistance in men.
X
ABCG5 p.Gln604Lys 15175352:101:4
status: NEW130 The Q604K polymorphism of the G5 gene was associated with insulin sensitivity, at least in men.
X
ABCG5 p.Gln604Lys 15175352:130:4
status: NEW