ABCG2 p.Val556Ser
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PMID: 17027309
[PubMed]
Li YF et al: "Towards understanding the mechanism of action of the multidrug resistance-linked half-ABC transporter ABCG2: a molecular modeling study."
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204
To test these possibilities, we made two mutants, F431S and V556S, and probed cell surface expression with the ABCG2 specific monoclonal antibody 5D3 [39] (Fig. 5A).
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ABCG2 p.Val556Ser 17027309:204:60
status: VERIFIED206 Flow cytometry analysis of ABCG2 mutants F431S and V556S.
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ABCG2 p.Val556Ser 17027309:206:51
status: VERIFIED207 (A) Using the 5D3 surface antibody, the F431S and V556S mutant proteins are detectable on the cell surface of HEK293 cells.
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ABCG2 p.Val556Ser 17027309:207:50
status: VERIFIED219 In particular, the residue V556 in the final model faces G498 in the TM3 helix of the neighboring subunit, explaining the phenotype for the V556S mutant because it faces a small residue.
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ABCG2 p.Val556Ser 17027309:219:140
status: VERIFIED