ABCG2 p.Phe431Ser
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PMID: 17027309
[PubMed]
Li YF et al: "Towards understanding the mechanism of action of the multidrug resistance-linked half-ABC transporter ABCG2: a molecular modeling study."
No.
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Comment
204
To test these possibilities, we made two mutants, F431S and V556S, and probed cell surface expression with the ABCG2 specific monoclonal antibody 5D3 [39] (Fig. 5A).
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ABCG2 p.Phe431Ser 17027309:204:50
status: VERIFIED206 Flow cytometry analysis of ABCG2 mutants F431S and V556S.
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ABCG2 p.Phe431Ser 17027309:206:41
status: VERIFIED207 (A) Using the 5D3 surface antibody, the F431S and V556S mutant proteins are detectable on the cell surface of HEK293 cells.
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ABCG2 p.Phe431Ser 17027309:207:40
status: VERIFIED
PMID: 20345483
[PubMed]
Kawahara H et al: "Pharmacological interaction with sunitinib is abolished by a germ-line mutation (1291T>C) of BCRP/ABCG2 gene."
No.
Sentence
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208
Li et al. reported that another mutant, F431S-BCRP, is still functional because pheophorbide A transport by F431S-BCRP was completely suppressed by FTC.
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ABCG2 p.Phe431Ser 20345483:208:40
status: VERIFIEDX
ABCG2 p.Phe431Ser 20345483:208:108
status: VERIFIED