ABCG2 p.Glu446Ala
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PMID: 17027309
[PubMed]
Li YF et al: "Towards understanding the mechanism of action of the multidrug resistance-linked half-ABC transporter ABCG2: a molecular modeling study."
No.
Sentence
Comment
177
Exhibit reduced transport of mitoxantrone, pheophorbide and basal ATPase activity [17] G406A, G410A, G406A/G410A TM1 Fully functional b E446A,D,G,H,K,R,S TM2 Loss of drug resistance [21] R482G,T,M,S, N,D,K,Y TM3 T or G change produces gain of function mutant.
X
ABCG2 p.Glu446Ala 17027309:177:136
status: VERIFIED