ABCG2 p.Val12Asn
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PMID: 16766035
[PubMed]
Cascorbi I et al: "Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs."
No.
Sentence
Comment
909
5.3. Association to activity and drug bioavailability HEK-293 cells, transfected with wild-type or V12N, ABCG2 showed apical staining with an ABCG2 antibody, but high intracellular staining in case of Q141K, suggesting impaired membrane trafficking or incorrect membrane insertion.
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ABCG2 p.Val12Asn 16766035:909:99
status: NEW930 In contrast, in a study by Mizuarai et al. (2004) V12N was found to be accumulated intracellulary and apical expression was observed by Kondo et al. (2004).
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ABCG2 p.Val12Asn 16766035:930:50
status: NEW
PMID: 19949922
[PubMed]
Cascorbi I et al: "Pharmacogenetics of ATP-binding cassette transporters and clinical implications."
No.
Sentence
Comment
231
HEK-293 cells, transfected with wild-type or V12N, ABCG2 showed apical staining with an ABCG2 antibody, but high intracellular staining in case of Q141K, suggesting impaired membrane trafficking or incorrect membrane insertion.
X
ABCG2 p.Val12Asn 19949922:231:45
status: NEW253 ABCG2 V12N protein was found to be accumulated intracellulary (120) and always apical expression was observed by Kondo et al.
X
ABCG2 p.Val12Asn 19949922:253:6
status: NEW