ABCG2 p.Cys284Ser
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PMID: 16367905
[PubMed]
Kage K et al: "Role of Cys-603 in dimer/oligomer formation of the breast cancer resistance protein BCRP/ABCG2."
No.
Sentence
Comment
58
Also under reducing conditions, the BCRP protein levels in PA/ C43S, PA/C55S, PA/C284S and PA/C603S cells were slightly lower than the levels in the wild-type transfectants.
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ABCG2 p.Cys284Ser 16367905:58:81
status: VERIFIED67 In contrast, the PA/C43S, PA/C55S, PA/C284S and PA/C603S mutants expressed intermediate amounts of BCRP and, in PA/C438S cells, little surface expression of BCRP was observed.
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ABCG2 p.Cys284Ser 16367905:67:38
status: VERIFIED108 PA/C43S, PA/C55S, PA/C284S and PA/C603S transfectants acquired similar or somewhat lower degrees of SN-38 resistance than PA/WT cells.
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ABCG2 p.Cys284Ser 16367905:108:21
status: VERIFIED130 In contrast, C43S, C55S and C284S mutations did not interfere with the overall function of BCRP, as these mutants conferred high levels of resistance to SN-38 (Fig. 5b).
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ABCG2 p.Cys284Ser 16367905:130:28
status: VERIFIED