ABCG2 p.Glu446Gly
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PMID: 14566825
[PubMed]
Miwa M et al: "Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants."
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Sentence
Comment
76
As shown in Figure 3, E446G-, R482G-, N557D- and H630L-BCRP were expressed on the cell surface.
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ABCG2 p.Glu446Gly 14566825:76:22
status: VERIFIED77 Expression levels of BCRP in PA/ WT2, PA/E446G and PA/R482G were similar. This suggests that trafficking problem is not a main reason for the loss of BCRP function in E446-mutants.
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ABCG2 p.Glu446Gly 14566825:77:41
status: VERIFIED